Roche says skin cancer drug shrinks significantly - Cancer & Health ...

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STOCKHOLM (Reuters) ? A new skin cancer drug, Roche had ?remarkable? results in a mid-stage trial, significantly shrinking tumors and lesions in patients with a potentially deadly form of skin cancer, said the Swiss drugmaker on Saturday.

Complete results from a mid-stage Phase II trial at the European Multidisciplinary Cancer Conference (EMCC) was presented in Stockholm, showed Roche vismodegib shrank tumors or lesions healed in 43 percent of men with locally advanced basal cell carcinoma (BCC) and 30 percent of those with another advanced form of the disease. ?It is difficult to estimate, if the photos just how remarkable the results have really seen,? Sandra Horning, Roche?s Global Head of Clinical Development Hematology and Oncology, told reporters at the conference. ?These are people who are really serious disfiguring disease, often in the face, in a way that it is very difficult for them to go out in public is. The really remarkable improvement in their appearance and pleasing shows clear how to improve the quality of life. ?

Basal cell carcinoma is the most common form of skin cancer in Europe, Australia and the United States, and there are some 2 million cases worldwide. It is usually treated surgically, and generally believed to cure if the cancer is confined to a small area of ??skin.

advanced cases of the disease, or those that spread and lead to secondary tumors that can weaken or distort those affected and can ultimately be life threatening. These cases are not always treatable with surgery, and there is currently no medical treatment available. Vismodegib is a type of drug as a ?hedgehog pathway inhibitor.? The Hedgehog signaling pathway is important in regulating proper growth and development in the early stages of life and becomes less active in adults. Mutations in the way of the hedgehog pathway is reactivated seen in various types of cancer, including BCC. ?This way to more than 90 percent of patients with basal cell carcinoma is activated,? said Horning. Roche had earlier this month it had the approval of his vismodegib in the market of the United States for the treatment of skin cancer. applied

Horning, said a similar request for approval in Europe was ?in progress?.

her partner, Curis is entitled to milestone payments and royalties under a cooperation agreement on the drug.

receive Phase II study reported at the EMCC 104 patients participating in the United States, Europe and Australia. The data showed seven patients died during the study, but none of these deaths was on the medication.

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Serious side effects, or so-called ?serious adverse events? were reported in 26 patients, and researchers said, four patients reported serious adverse events associated with vismodegib.

(Dan Lalor section, John Stonestreet)

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